| Date | Location | Result | |
| 03/17/22 | Philadelphia, Pa. (Daskalakis Ath. Ctr.) | Drexel 54, Norfolk State 47 | Box score |
| 03/12/22 | Norfolk, Va. (Scope Arena) | Howard 61, Norfolk State 44 | Box score |
| 03/11/22 | Norfolk, Va. (Scope Arena) | Norfolk State 53, Morgan State 51 | Box score |
| 03/09/22 | Norfolk, Va. (Scope Arena) | Norfolk State 58, N.C. Central 52 | Box score |
| 03/03/22 | Norfolk, Va. (Echols Hall) | Norfolk State 62, Howard 58 | Box score |
| 02/28/22 | Norfolk, Va. (Echols Hall) | Norfolk State 71, N.C. Central 63 | Box score |
| 02/26/22 | Norfolk, Va. (Echols Hall) | Norfolk State 68, South Carolina State 29 | Box score |
| 02/21/22 | Baltimore, Md. (Hill Field House) | Morgan State 51, Norfolk State 48 | Box score |
| 02/19/22 | Baltimore, Md. (PEC Arena) | Coppin State 56, Norfolk State 48 | Box score |
| 02/14/22 | Dover, Del. (Memorial Hall) | Norfolk State 76, Delaware State 31 | Box score |
| 02/12/22 | Norfolk, Va. (Echols Hall) | Norfolk State 66, UMES 52 | Box score |
| 02/10/22 | Washington, D.C. (Burr Gymnasium) | Howard 71, Norfolk State 67 | Box score |
| 02/07/22 | Princess Anne, Md. (Hytche Arena) | Norfolk State 53, Maryland Eastern Shore 48 | Box score |
| 02/05/22 | Norfolk, Va. (Echols Hall) | Norfolk State 102, Delaware State 36 | Box score |
| 01/29/22 | Orangeburg, S.C. (SHM Memorial Gym) | Norfolk State 60, S.C. State 40 | Box score |
| 01/24/22 | Norfolk, Va. (Echols Hall) | Norfolk State 64, Morgan State 52 | Box score |
| 01/22/22 | Norfolk, Va. (Echols Hall) | Norfolk State 71, Coppin State 60 | Box score |
| 01/10/22 | Durham, N.C. (McDougald-McLendon Arena) | Norfolk State 80, N.C. Central 70 | Box score |
| 12/19/21 | Williamsburg, Va. (Kaplan Arena) | William & Mary 55, Norfolk State 50 | Box score |
| 12/16/21 | Norfolk, Va. (Echols Hall) | Norfolk State 67, UNCW 56 | Box score |
| 12/12/21 | Norfolk, Va. (Chartway Arena) | Old Dominion 76, Norfolk State 47 | Box score |
| 12/06/21 | Fairfax, Va. (EagleBank Arena) | Norfolk State 66, George Mason 59 | Box score |
| 12/04/21 | Hampton, Va. (HU Convocation Center) | Hampton 56, Norfolk State 52 | Box score |
| 11/27/21 | Norfolk, Va. (Echols Hall) | Air Force 54, Norfolk State 41 | Box score |
| 11/19/21 | Norfolk, Va. (Echols Hall) | Col. of Charleston 66, Norfolk State 62 | Box score |
| 11/16/21 | Bloomington, Ind. (Assembly Hall) | Indiana 72, Norfolk State 42 | Box score |
| 11/14/21 | Columbus, Ohio (Value City Arena) | Ohio State 86, Norfolk State 48 | Box score |
| 11/11/21 | Buies Creek, N.C. (Gore Arena) | Norfolk State 65, Campbell 49 | Box score |
| 11/09/21 | Norfolk, Va. (Echols Hall) | Norfolk State 81, Chowan 53 | Box score |